Award
National Cancer Institute 1R15CA290595-01A1
Deciphering novel UPS regulation of Sgf73/ataxin-7 in controlling SAGA and associated functions in gene expression
Recipient
Southern Illinois University Carbondale
Award Amount
$445,500.00
Ceiling
$445,500.00
Awarded
August 08, 2025
Identifier
1R15CA290595-01A1
NIH research grant awarded to Southern Illinois University Carbondale to study the regulation of Sgf73/ataxin-7 via the ubiquitin-proteasome system and its role in gene expression and disease.
Description
This project aims to identify the factors involved in the regulation of Sgf73/ataxin-7, including E3 ubiquitin ligase, ubiquitin sites, and other factors involved in its ubiquitylation and degradation. The research will elucidate the role of UPS in gene regulation and its implications for disease pathogenesis and therapeutic development.