Award
NIH Reporter #1R21AG089266-01
The mechanisms of cerebral microcirculation response to transcranial stimulation.
Recipient
Olga A. Bragina
Award Amount
$596,750.00
Ceiling
$596,750.00
Awarded
September 10, 2024
Identifier
1R21AG089266-01
The project investigates the effects of transcranial electrical stimulation on brain microvasculature and neuronal activity, aiming to elucidate the mechanisms of tACS and tDCS on cerebral microcirculation and endothelial function.
Description
This project aims to define how two types of transcranial electrical stimulation (tES), alternating current stimulation (tACS) and direct current stimulation (tDCS), affect neurons and cells of the brain microvasculature. The research includes in-vivo awake multiphoton laser scanning microscopy to study cerebral microvascular tone, circulation, and blood-brain barrier permeability during and after tACS and tDCS, using nitric oxide synthase modulators and knockout mice. The goal is to understand the mechanisms of tES effects on vascular endothelium and cerebral microcirculation and their influence on neuronal activity.