Award
Massachusetts General Hospital 11228405
Deciphering the Role of Reductive Stress in Non Small Cell Lung Cancer
Recipient
Massachusetts General Hospital
Award Amount
$384,300.00
Ceiling
$384,300.00
Awarded
December 10, 2025
Identifier
11228405
Research project funded by the National Cancer Institute to study NRF2's role in non-small cell lung cancer using advanced technologies, aiming to develop new therapeutics.
Description
The project involves advanced metabolomic, chemical-proteomic, and genomic technologies to study NRF2's role in non-small cell lung cancer. The research aims to understand how NRF2 regulation affects mitochondrial metabolism and cell proliferation. The project is funded by the National Cancer Institute (NCI) under grant PA-20-185. The project includes a comprehensive approach using chemical proteomics, genome-wide CRISPR screens, and untargeted metabolomics. The goal is to develop translational therapeutics for lung cancer patients with deregulated NRF2 signaling.