Award
National Institute of Neurological Disorders and Stroke 11370582
Mechanisms of Thalamocortical Dysfunction and Social Deficits in FTD due to GRN Mutations
Recipient
National Institute of Neurological Disorders and Stroke (NINDS)
Award Amount
$404,304.00
Ceiling
$404,304.00
Awarded
June 23, 2026
Identifier
11370582
Research project funded by the National Institute of Neurological Disorders and Stroke to study mechanisms of FTD caused by GRN mutations and develop potential therapies.
Description
The project focuses on investigating the cellular and molecular mechanisms by which progranulin insufficiency causes FTD, aiming to identify the cellular site of action for progranulin-boosting therapy. The project involves developing a lysosome-targeted progranulin viral vector and testing its effects in primary cortical neurons and mouse models. The project aims to advance understanding of FTD-GRN pathogenesis and inform therapy development.