Award
National Institute of General Medical Sciences 1R35GM162850-01
DIRECTED EVOLUTION OF BIOCATALYSTS FOR ASYMMETRIC HYDROGEN ATOM TRANSFER REACTIONS
Recipient
University of California Los Angeles
Award Amount
$420,981.00
Ceiling
$420,981.00
Awarded
February 27, 2026
Identifier
1R35GM162850-01
This award funds research to develop enzymatic catalysts for asymmetric hydrogen atom transfer reactions, integrating biocatalysis with metal-hydride-mediated radical chemistry to enhance pharmaceutical synthesis and drug discovery.
Description
The project focuses on the precise control of radical-mediated reactions in synthetic chemistry, aiming to develop enzymatic platforms for asymmetric olefin functionalization through biocatalysis and metal-hydride-mediated radical chemistry. The research will provide tools for pharmaceutical synthesis, enabling efficient production of bioactive molecules and accelerating drug discovery.