Award
NIH Reporter #1R01AR083994-01A1
Investigating the role of A20 and DREAM in adipogenesis and systemic sclerosis
Recipient
University of Michigan at Ann Arbor, MI
Award Amount
$637,567.00
Ceiling
$637,567.00
Awarded
September 17, 2025
Identifier
1R01AR083994-01A1
This NIH grant funds research to understand the role of A20 and DREAM in adipogenesis and fibrosis related to systemic sclerosis, aiming to develop novel therapeutic strategies.
Description
Researchers will investigate mechanisms by which A20 promotes adipogenesis and how low A20 levels in scleroderma (SSc) patients lead to transdifferentiation of adipocytes to mesenchymal phenotype, initiating fibrosis. The study will explore whether blocking DREAM, a suppressor of A20, can restore A20 activity and reduce fibrosis.