Award
National Cancer Institute 5R01CA291986-02
Targeting Early Drivers of Prostate Cancer Lineage Plasticity
Recipient
University of Michigan at Ann Arbor
Award Amount
$500,241.00
Ceiling
$500,241.00
Awarded
March 25, 2026
Identifier
5R01CA291986-02
NIH awarded a research grant to the University of Michigan at Ann Arbor to study early drivers of prostate cancer lineage plasticity, aiming to identify key transcriptional regulators and develop targeted therapies.
Description
This NIH research grant focuses on understanding and targeting early drivers of prostate cancer lineage plasticity through genomic analysis, mechanistic studies, and in vivo targeting strategies. The project aims to determine mechanisms by which key transcriptional regulators modulate differentiation state and cancer hallmarks, how these regulators are upregulated in human tumors, and the effect of targeting these regulators in vivo.