Award
NIH Reporter #1K23DK149057-01
Mechanisms of sarcopenia in childhood chronic liver disease: Muscle mitochondrial dysfunction and protein catabolism
Recipient
University of Colorado Denver
Award Amount
$193,351.00
Ceiling
$193,351.00
Awarded
July 22, 2026
Identifier
1K23DK149057-01
Research project focused on understanding sarcopenia in children with chronic liver disease by studying muscle mitochondrial dysfunction and protein catabolism to inform future treatments.
Description
This project investigates mitochondrial dysfunction, oxidative stress, imbalances in protein metabolism, and bile acid perturbations in skeletal muscle to define relationships with sarcopenia in children with chronic cholestasis. The findings aim to fill critical gaps in knowledge to inform future therapeutic interventions.