Award
National Cancer Institute 5K08CA259161-05
Uncovering Epigenetic and Transcriptional Drivers of Neuroendocrine Plasticity at Single-Cell Level in Patients with Small Cell Lung Cancer Transformation
Recipient
Sloan-Kettering Institute for Cancer Research
Award Amount
$278,198.00
Ceiling
$278,198.00
Awarded
January 16, 2026
Identifier
5K08CA259161-05
This award supports research to uncover molecular drivers of neuroendocrine plasticity in small cell lung cancer at the single-cell level, involving advanced training and preclinical model experiments.
Description
The project focuses on the molecular drivers of neuroendocrine lineage plasticity in lung cancer using single-cell sequencing and functional experiments in preclinical models. It aims to identify transcriptomic and epigenetic changes driving lineage plasticity and involves advanced computational and wet lab training for the principal investigator. The project is supported by the NIH grant PA-20-203.