Award
NIH Reporter #5R35GM150625-04
Using Experimental Evolution to Evaluate Environmental Effects on Microbial Mutation and Adaptation
Recipient
Vanderbilt University, Nashville, TN
Award Amount
$396,127.00
Ceiling
$396,127.00
Awarded
July 31, 2026
Identifier
5R35GM150625-04
A research project funded by NIGMS at Vanderbilt University to study microbial adaptation and mutation under varying oxygen and nutrient conditions using experimental evolution techniques.
Description
This project investigates how oxygen availability influences microbial evolution during feast/famine conditions using experimental evolution with Escherichia coli and Lactobacillus crispatus. The study characterizes adaptive mutations, physiological changes, and mutation spectra to understand evolutionary processes in neglected microbial environments.