Award
National Institute on Aging 2R56AG069858-05A1
Regulation of eicosanoid signaling lipids to improve skeletal muscle function and increase healthspan during aging
Recipient
Stanford University
Award Amount
$386,677.00
Ceiling
$386,677.00
Awarded
July 21, 2026
Identifier
2R56AG069858-05A1
The award supports research at Stanford University to understand and improve muscle function during aging by regulating eicosanoid signaling lipids, specifically targeting PGE2 and its regulation by 15-PGDH to promote muscle hypertrophy and strength in older adults.
Description
This project aims to develop therapeutic strategies to counteract muscle aging by targeting PGE2 signaling pathways, with potential implications for improving quality of life in older adults. It focuses on the role of Prostaglandin E2 (PGE2) and the enzyme 15-prostaglandin dehydrogenase (15-PGDH) in muscle repair and strength, hypothesizing that restoring PGE2 levels can overcome anabolic resistance in aging muscles.