Award
NIH Reporter #5F31CA290924-02
Determining the Mechanism of Rhabdomyosarcoma Transformation from a Non-Myogenic Cell of Origin
Recipient
ST. JUDE CHILDREN'S RESEARCH HOSPITAL GRADUATE SCHOOL OF BIOMEDICAL SCIENCES, LLC
Award Amount
$49,114.00
Ceiling
$49,114.00
Awarded
May 07, 2026
Identifier
5F31CA290924-02
Research project funded by the National Cancer Institute to study the molecular mechanisms of rhabdomyosarcoma transformation from non-myogenic cells.
Description
This project aims to uncover the mechanisms behind the transformation of non-myogenic cells into rhabdomyosarcoma (RMS), a pediatric soft tissue sarcoma. The research focuses on defining chromatin landscape changes and identifying transcription factors necessary for RMS development, using a mouse model driven by oncogenic Sonic hedgehog signaling.