Award
California Department of Veterans Affairs BX-23-001
Right Heart Function in Health and Chronic Disease
Recipient
Veterans Affairs Medical Center San Francisco
Awarded
October 03, 2025
Identifier
BX-23-001
A Veterans Affairs funded research project investigating treatments for right ventricular failure in veterans, focusing on mitochondrial function and α1A-adrenergic receptor stimulation.
Description
Research grant focused on cardiovascular health in veterans, specifically on right ventricular failure and mitochondrial function. The project aims to determine mechanisms involved in α1A-AR-mediated reversal of mitochondrial dysfunction and right ventricular failure, including effects on mitochondrial respiration, antioxidant defenses, and protein hyperacetylation, and to evaluate effects on human engineered heart tissue derived from induced pluripotent stem cell-derived cardiomyocytes.