Award
National Institute of General Medical Sciences 5R16GM150784-04
The Impact of Disrupting Sensory Innervation on Tibial Bone Mass
Recipient
University of New England
Award Amount
$177,500.00
Ceiling
$177,500.00
Awarded
July 16, 2026
Identifier
5R16GM150784-04
NIH awarded a research grant to study the impact of saphenous nerve injury on tibial bone mineral density, aiming to identify new risk factors for tibial fractures and improve prevention.
Description
This NIH-funded research project explores the role of saphenous nerve injury in controlling tibial bone mineral density through sensory nerves. The study aims to characterize the impact of saphenous nerve transection on tibial bone mass and innervation and assess the contribution of sensory nerve fiber subtypes on tibial bone mass through chemical ablation of peptidergic and non-peptidergic sensory neurons. The research seeks to understand how nerve injury affects bone mass to reveal new risk factors for tibial fractures and inform preventative strategies.