Award
National Institute on Drug Abuse 4U01DA054182-06
Correlating molecular behavioral phenotypes in a marmoset model of Huntington's disease
Recipient
Rockefeller University, New York, NY, United States
Award Amount
$786,192.00
Ceiling
$786,192.00
Awarded
June 08, 2026
Identifier
4U01DA054182-06
This NIH grant supports research on creating transgenic primate models for Huntington's disease, focusing on genetic engineering, stem cell biology, and behavioral analysis to advance understanding of neurodegenerative diseases.
Description
The project aims to establish a primate model for Huntington's disease using transgenic marmosets. It involves creating germline transmissible models with gene reporters and trinucleotide repeat genes, overcoming low homologous recombination efficiency, and utilizing ground-state pluripotent stem cells. The project will generate transgenic knock-in cjPSCs, develop chimeric marmosets, and analyze molecular-behavioral phenotypes, focusing on neuronal populations. The outcomes will provide insights into neurodegenerative diseases and establish marmosets as a valuable model for neurological research.