Award
National Institute of General Medical Sciences 5R35GM128855-08
Spindle Assembly Checkpoint Silencing
Recipient
University of North Carolina at Chapel Hill, Department of Pharmacology
Award Amount
$454,118.00
Ceiling
$454,118.00
Awarded
July 25, 2025
Identifier
5R35GM128855-08
Research project funded by NIGMS to study cell cycle regulation and spindle assembly checkpoint mechanisms, with implications for cancer and developmental defects.
Description
The project focuses on understanding the regulation of the cell cycle, specifically the spindle assembly checkpoint (SAC) and the role of the Anaphase-Promoting Complex/Cyclosome (APC/C) in mitosis and gene expression. The research aims to reconstitute processes in vitro using techniques such as cryo-EM and mass photometry to elucidate mechanisms of polyubiquitination, conformational states of MCC-bound APC/C, and nucleosome targeting.