Award
National Cancer Institute 1R01CA304244-01
Development of nanoscale infrared spectroscopic imaging for measuring cellular ultrastructure
Recipient
University of Illinois at Urbana-Champaign, Champaign, IL
Award Amount
$573,470.00
Ceiling
$573,470.00
Awarded
August 22, 2025
Identifier
1R01CA304244-01
NIH grant awarded to develop advanced nanoscale infrared spectroscopic imaging technology for cellular ultrastructure analysis, enhancing resolution and sensitivity for biomedical research.
Description
This project aims to develop a new AFM-IR technology, dubbed resonance enhance null-deflection IR (RENDIR) spectroscopic imaging, to overcome current limitations such as mechanical artifacts, high noise, and low sensitivity. Objectives include developing custom electronics, optimizing data recording, expanding optical range, integrating novel optics, validating performance, and using biological models to identify subcellular domains and metabolites with improved resolution, noise, sensitivity, and data acquisition speed.