Award
National Institute of Arthritis and Musculoskeletal and Skin Diseases 5R01AR070736-08
Uncovering the role of Setbp1 in fibroblast-like synoviocytes during inflammatory arthritis
Recipient
Emory University
Award Amount
$415,871.00
Ceiling
$415,871.00
Awarded
July 30, 2026
Identifier
5R01AR070736-08
NIH grant awarded to Emory University to study the role of SETBP1 in fibroblast-like synoviocytes for inflammatory arthritis treatment, focusing on epigenetic regulation and therapeutic targeting.
Description
This project aims to investigate the role of the epigenetic hub protein SETBP1 in regulating the transformation of fibroblast-like synoviocytes (FLS) in rheumatoid arthritis. The research will focus on understanding how SETBP1 acts as an epigenetic switch to repress pro-inflammatory and anti-inflammatory genes, potentially serving as a therapeutic target to prevent drug resistance and symptom recurrence in autoimmune joint diseases.