Award
National Cancer Institute 5R01CA260855-09
NANOPHOTOSENSITIZERS FOR REGENERATIVE PHOTOTHERAPY
Recipient
UT Southwestern Medical Center, Dallas, TX
Award Amount
$675,432.00
Ceiling
$675,432.00
Awarded
July 21, 2025
Identifier
5R01CA260855-09
This NIH-funded project focuses on developing nanophotosensitizers for cancer and bone lesion treatment, aiming to overcome phototherapy limitations by using radionuclide-stimulated therapy to enhance treatment efficacy.
Description
The project aims to develop an oxygen- and tissue depth-independent nano-phototherapy platform using nanophotosensitizers to treat cancer and bone lesions. The research includes methods to deliver large amounts of nanoparticles to tumors, destroy supportive cells, and explore combined eradication strategies to improve treatment outcomes. The study will also address limitations of current phototherapy, such as light penetration and hypoxia, by leveraging radionuclide-stimulated therapy involving Cerenkov radiation to generate reactive oxygen species for effective treatment.