Award
NIH Reporter #1F32GM163363-01
Leveraging genetic divergence to uncover mechanisms of genomic organization
Recipient
University of Wisconsin-Madison
Award Amount
$76,300.00
Ceiling
$76,300.00
Awarded
April 01, 2026
Identifier
1F32GM163363-01
The award supports research on genome organization and gene expression regulation during embryogenesis, focusing on the GAGA factor's role in nuclear compartmentalization in Drosophila embryos.
Description
This project aims to understand how the genome is structured and interpreted to give rise to diverse cell types by studying nuclear organization during embryogenesis in Drosophila. It focuses on the role of the transcription factor GAGA factor (GAF) in establishing active and inactive nuclear compartments, gene expression, and silencing repetitive DNA. The research uses evolutionary, biochemical, and genetic approaches to elucidate molecular mechanisms of genome partitioning with implications for development and cancer.