Award
National Institute of Neurological Disorders and Stroke 5R01NS121316-03
Recovering amnestic memories from the repeat head impact brain
Recipient
Georgetown University, Washington, DC, United States
Award Amount
$342,000.00
Ceiling
$342,000.00
Awarded
July 24, 2025
Identifier
5R01NS121316-03
NIH grant awarded to Georgetown University to study brain changes from repeated head impacts and develop treatments to restore memory and reduce dementia risk.
Description
This project investigates the physiological changes in the brain caused by head impacts (HI) and their relation to memory impairments and dementias, including Alzheimer’s disease. The research focuses on the effects of high-frequency non-damaging HI and compares it to severe traumatic brain injury (TBI). Preliminary data indicates that repeated head impacts cause adaptive responses in excitatory synapses, leading to long-term impairments in learning and memory. The goal is to determine if chronic synaptic dysfunction can be reversed to restore forgotten memories.