Award
NIH Reporter #5R01EY036444-02
Point-of-Care Metagenomics for Rapid Detection of pathogens and Antimicrobial Resistance in Sight-Threatening Ocular Infections
Recipient
Massachusetts Eye and Ear Infirmary, Boston, MA, United States
Award Amount
$361,250.00
Ceiling
$361,250.00
Awarded
September 19, 2025
Identifier
5R01EY036444-02
This multi-year, substantial contract was awarded to support the development of a cutting-edge diagnostic technology for eye infections. The project involves creating a rapid, culture-independent testing method using metagenomic sequencing and bioinformatics, aimed at improving detection of pathogens and antimicrobial resistance. The recipient, based in Boston, is engaged in biomedical research and innovation. The work includes developing and validating sequencing approaches, clinical validation, and designing a user-friendly diagnostic device tailored to patient needs. The award signifies a significant advancement in ocular infection management, with potential impacts on clinical outcomes and antimicrobial stewardship. The contract was awarded on a non-competitive basis, justified by the specialized nature of the project. The award is part of a broader effort to enhance diagnostic capabilities in ophthalmology and infectious disease sectors.
Description
This project aims to develop a rapid, culture-independent diagnostic tool for ocular infections using metagenomic sequencing and bioinformatics. It addresses critical issues related to antimicrobial resistance in ocular pathogens and involves developing and validating sequencing approaches, clinical validation, and creating a diagnostic tool tailored to patient needs.