Award
National Institute of Neurological Disorders and Stroke 1RF1NS132784-01
Biophysical Mechanisms of Cortical MicroStimulation
Recipient
Massachusetts General Hospital, Boston, MA, United States
Award Amount
$3,360,184.00
Ceiling
$3,360,184.00
Awarded
September 05, 2023
Identifier
1RF1NS132784-01
The award supports research to elucidate the mechanisms of cortical microstimulation to improve neuromodulation therapies for brain disorders, combining experimental and computational approaches in human and mouse models.
Description
This project aims to understand the biophysical mechanisms of cortical microstimulation using single-cell electrophysiology, pharmacology, optical physiology, and computational modeling in both human and mouse cortex. The goal is to develop targeted neuromodulation therapies for neuropsychiatric disorders by identifying how direct local electrical stimulation affects neural activity and designing specific stimulation patterns.