Award
National Institute of General Medical Sciences 5R01GM086596-13
Activation of androgen biosynthesis and drug metabolism by cytochrome b5
Recipient
University of Michigan at Ann Arbor
Award Amount
$405,600.00
Ceiling
$405,600.00
Awarded
July 29, 2026
Identifier
5R01GM086596-13
NIH funded research to study cytochrome b5's role in testosterone biosynthesis and drug metabolism, aiming to develop safer prostate cancer treatments by targeting enzyme activity with fewer side effects.
Description
This NIH grant project focuses on understanding the biochemical and biophysical properties of the cytochrome b5-P450 17A1 complex to develop safer inhibitors for testosterone production, aiming to improve treatments for diseases like prostate cancer and polycystic ovary syndrome. The project involves advanced spectroscopy, mutagenesis, and molecular dynamics studies to elucidate enzyme mechanisms and develop selective inhibitors with fewer side effects.