Award
National Institute of Mental Health 1R01MH142417-01
The roles of Rett Syndrome protein MECP2 at gene regulatory elements
Recipient
UT SOUTHWESTERN MEDICAL CENTER
Award Amount
$641,828.00
Ceiling
$641,828.00
Awarded
March 03, 2026
Identifier
1R01MH142417-01
This award funds research on the molecular mechanisms of MECP2 protein in Rett Syndrome, aiming to understand gene regulation and identify therapeutic targets.
Description
The project focuses on the molecular mechanisms of MECP2 in Rett Syndrome. The study aims to understand how MECP2 regulates genes and how its dysregulation leads to Rett Syndrome, focusing on MECP2 binding hotspots (MBHs) and their role in repressing enhancer activity. The project will define the interaction between MECP2 and MBHs and elucidate the mechanisms by which MBHs repress enhancers, potentially uncovering new therapeutic targets.