Award
National Heart, Lung, and Blood Institute 5R01HL167955-03
MDM2-HIF signaling in pathological ventricular remodeling
Recipient
University of Pittsburgh at Pittsburgh
Award Amount
$729,311.00
Ceiling
$729,311.00
Awarded
April 27, 2026
Identifier
5R01HL167955-03
A research project funded by the National Heart Lung and Blood Institute to study the role of MDM2-HIF signaling in pathological ventricular remodeling and heart failure, aiming to identify new therapeutic targets for cardiomyopathy.
Description
This project focuses on understanding the molecular pathways regulating pathological heart growth and heart failure, specifically investigating the role of MDM2-HIF signaling axis in ventricular remodeling. The research aims to define how this pathway influences microvasculature dysfunction, myocardial metabolism, and pressure overload responses in the heart, with the goal of identifying novel therapeutic targets for cardiomyopathy.