Award
NIH Reporter #2R15AI130950-03A1
Distinguishing features of C. albicans pseudouridylation and their roles in pathogenesis
Recipient
Ball State University, Muncie, IN, United States
Award Amount
$549,460.00
Ceiling
$549,460.00
Awarded
September 16, 2025
Identifier
2R15AI130950-03A1
Research project funded by NIH to study molecular differences in fungal pathogens to develop antifungal treatments, focusing on RNA modifications in C. albicans and C. auris.
Description
This project aims to develop more effective antifungal treatment options by understanding the molecular differences between fungal pathogens and humans, focusing on pseudouridine synthesis and degradation in C. albicans and C. auris. The research involves characterizing RNA modification processes, exploring the effects of heavy metals on Pus1 localization, and investigating pseudouridine degradation's role in virulence and antifungal tolerance.