Award
NIH Reporter #11372134
Development and validation of an autologous mouse model for the study of immune interactions with glioblastoma
Recipient
University of Pennsylvania
Award Amount
$727,211.00
Ceiling
$727,211.00
Awarded
June 03, 2026
Identifier
11372134
The award supports the development of a humanized mouse model using autologous patient-derived tumor and immune cells to study immune interactions and immunotherapy responses in glioblastoma, aiming to improve translational research relevance.
Description
This project aims to develop and characterize an autologous humanized mouse model for studying immunotherapies in glioblastoma, using tumor tissue and matched immune cells from the same patient to ensure clinical relevance. The model will be validated by generating CAR T cells from the same patient and comparing treatment outcomes to patient data.