National Institute of General Medical Sciences 5R35GM145257-05

Translation regulation by molecular switch RNA-binding protein LARP1

This NIH-funded research project aims to understand how the RNA-binding protein LARP1 regulates gene expression at the translation stage by integrating multiple molecular signals. The study will provide insights into translation regulation mechanisms and potential therapeutic targets.

Description

The goal of this research program is to uncover the molecular mechanisms underlying RNA-binding protein (RBP) regulation of the decisive stage of gene expression, translation. The project will use the RBP La-related protein 1 (LARP1) as a model system to understand how cells integrate information from multi-RBD RBPs, post-translational modifications, and post-transcriptional mRNA modifications to direct the translation of specific transcripts. The research involves biochemistry, biophysics, and structural biology to address fundamental questions of translation regulation.

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