Award
National Heart, Lung, and Blood Institute 11160887
The role of notch modulation in spatially defined hematopoiesis
Recipient
Harvard Medical School
Award Amount
$44,367.00
Ceiling
$44,367.00
Awarded
August 22, 2025
Identifier
11160887
This NIH-funded project by Harvard Medical School investigates NOTCH signaling in spatially defined hematopoiesis to improve long-term hematopoietic stem cell production from human induced pluripotent stem cells for blood disorder treatments.
Description
Human induced pluripotent stem cell (hiPSC) derived hematopoietic stem cells (HSCs) offer a scalable source of HSCs for the treatment of blood disorders; however, current protocols deriving HSCs from hiPSCs are largely devoid of long-term reconstitution potential. The project aims to characterize spatially defined hematopoiesis in HSC-producing arteries, focusing on NOTCH modulators that control site-specific differences in hematopoiesis, with the goal of discovering methods to enhance long-term HSC production from hiPSC.