Award
NIH Reporter #5U54CA272688-04
Lynch Vaccine
Recipient
WEILL MEDICAL COLL OF CORNELL UNIV, NEW YORK, NY, UNITED STATES
Award Amount
$651,492.00
Ceiling
$651,492.00
Awarded
September 01, 2025
Identifier
5U54CA272688-04
This award funds research to develop a neoantigen vaccine for Lynch syndrome-associated colorectal cancer using RNA nanoparticle technology, aiming to enhance immune response and reduce tumor burden.
Description
The project focuses on developing a neoantigen-based vaccine for Lynch syndrome-associated colorectal cancer using an LNP-RNA vaccine platform. It aims to test if LNP-RNA rFSP vaccination elicits immune responses, reduces tumor burden, and identifies the most immunogenic neoantigens for vaccine development and clinical trials.