Award
National Cancer Institute 1R37CA299197-01A1
Role of ATAD2 in Prostate Cancer Progression and Metastasis
Recipient
ICHAN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY, UNITED STATES
Award Amount
$682,886.00
Ceiling
$682,886.00
Awarded
April 21, 2026
Identifier
1R37CA299197-01A1
The award supports research on the role of ATAD2 in prostate cancer metastasis, particularly to bone, using innovative models to identify mechanisms for potential targeted therapies.
Description
This project aims to understand the functional determinants of progression to lethal metastatic prostate cancer, focusing on the role of ATAD2 in bone colonization and antitumoral immune responses. It uses advanced models including mouse models, epigenetic editing, and human organoids to uncover mechanisms linking metastasis and immune escape for targeted therapy development.