Award
NIH Reporter #4R01AG078677-02
Investigating the role and therapeutic potential of the alpha5beta1 integrin in risk factors for COVID-19-associated cognitive impairment
Recipient
Tulane University of Louisiana, New Orleans, LA
Award Amount
$721,756.00
Ceiling
$721,756.00
Awarded
April 06, 2026
Identifier
4R01AG078677-02
Research project funded by the National Institute on Aging to study the role of alpha5beta1 integrin in COVID-19-associated cognitive impairment and vascular dementia, evaluating the therapeutic potential of integrin inhibition.
Description
This project investigates the association between vascular dementia and COVID-19-related cognitive decline, focusing on the role of the alpha5beta1 integrin receptor. It explores the therapeutic potential of the integrin inhibitor ATN-161 to lessen blood-brain barrier disruption and cognitive impairment in models of vascular dementia and COVID-19 infection.