Award
National Heart, Lung, and Blood Institute 5R01HL166274-04
S-acylation-dependent regulation of cytokine receptor signaling and cardiac maladaptation
Recipient
University of Michigan at Ann Arbor
Award Amount
$471,296.00
Ceiling
$471,296.00
Awarded
February 18, 2026
Identifier
5R01HL166274-04
The award supports research on the role of protein S-acylation in regulating cytokine receptor signaling in heart cells, aiming to understand and potentially treat cardiac hypertrophy and heart failure by studying the zDHHC9 enzyme and Jak1 protein modifications.
Description
This project investigates how zDHHC9-regulated S-acylation of Jak1 promotes its trafficking to cytokine receptors, Stat3 activation, and maladaptive cardiac remodeling. The study aims to uncover mechanisms of intracellular signaling in cardiomyocytes related to cardiac hypertrophy and heart failure, focusing on lipid modifications and their role in signal transduction.