Award
National Institute of Neurological Disorders and Stroke 5R33NS126618-03
Evaluation of a specific LXR/PPAR agonist for treatment of Alzheimer's disease
Recipient
Auburn University at Auburn
Award Amount
$344,798.00
Ceiling
$344,798.00
Awarded
February 19, 2026
Identifier
5R33NS126618-03
NIH funded project to evaluate a novel LXR/PPAR agonist (AU403) for Alzheimer's disease treatment focusing on safety, efficacy, pharmacokinetics, and potential clinical development.
Description
This project aims to evaluate AU403, a novel LXRβ/PPAR agonist, for safety and efficacy in Alzheimer's disease mouse models, including pharmacokinetics, safety assessments, and efficacy testing in preventative and treatment models. The study will also explore the impact of AU403 on brain energy regulation and neuroinflammatory pathways, supporting potential clinical development.