Award
National Heart, Lung, and Blood Institute 5R01HL164891-04
Protein tyrosine phosphatase non-receptor 14 in vascular stability and remodeling
Recipient
University of California, San Francisco
Award Amount
$699,899.00
Ceiling
$699,899.00
Awarded
January 29, 2026
Identifier
5R01HL164891-04
Research project funded by NHLBI to study the role of PTPN14 in vascular stability and remodeling using genetic and molecular methods, aiming to understand mechanisms underlying vascular malformations and develop targeted therapies.
Description
The project investigates the role of PTPN14 in vascular and lymphatic vessel homeostasis, its genetic variations associated with pulmonary arteriovenous malformations (AVMs), and its interactions with signaling pathways such as YAP and BMP9-endoglin-ALK1. The study employs human engineered microvessels, in vivo mouse models with endothelial-specific gene modifications, and advanced imaging techniques like micro-CT to understand vascular development and malformations.