Award
National Heart, Lung, and Blood Institute 2R01HL155426-05
Inflammation-Driven Clonal Evolution in RUNX1 Carriers: Mechanisms and Therapeutic Vulnerabilities
Recipient
Oregon Health & Science University
Award Amount
$610,540.00
Ceiling
$610,540.00
Awarded
July 27, 2026
Identifier
2R01HL155426-05
NIH grant awarded to Oregon Health & Science University for research on clonal evolution in RUNX1 carriers, aiming to develop therapeutic interventions to prevent leukemia progression.
Description
The project focuses on understanding mechanisms of clonal evolution in RUNX1-FPD and exploring therapeutic interventions. The project involves advanced techniques such as CRISPR editing, single-cell OMICS, and spatial imaging. The goal is to establish early intervention strategies to prevent leukemia progression in high-risk patients.