Award
National Heart, Lung, and Blood Institute PA-20-188
Tailored siRNA delivery to human endothelium to inhibit and reverse inflammatory damage following ischemia reperfusion injury in the kidney
Recipient
Villanova University
Award Amount
$245,275.00
Ceiling
$245,275.00
Awarded
August 16, 2024
Identifier
PA-20-188
NIH grant to develop polymeric nanoparticle-based siRNA delivery targeting endothelial cells to reduce inflammation and damage in kidney transplants caused by ischemia reperfusion injury.
Description
This project aims to develop a multi-faceted therapeutic strategy to reduce ischemia reperfusion injury (IRI) related damage to the endothelium of transplanted kidneys. The approach involves using polymeric vehicles tailored for endothelial cells to deliver and sustain the release of siRNA, thereby preventing injury outcomes by silencing key molecules that propagate inflammation.