Award
NIH Reporter #1K99HL181288-01
Decoding Nuclear Mechanosignaling and Epigenetic Mediators of Mechanical Memory in Cardiomyocytes
Recipient
University of Pennsylvania, Philadelphia, PA, United States
Award Amount
$169,020.00
Ceiling
$169,020.00
Awarded
September 19, 2025
Identifier
1K99HL181288-01
Research project to study mechanical memory in cardiomyocytes by investigating nuclear signaling, epigenetic regulation, and DNA damage response, aiming to develop therapies for heart disease.
Description
This project aims to understand how mechanical forces influence nuclear signaling and epigenetic regulation in cardiomyocytes, focusing on the phenomenon of mechanical memory (MM). The research will investigate the molecular pathways, epigenetic landscapes, and DNA damage responses involved in persistent cellular changes due to extracellular stiffening, with potential therapeutic implications for heart disease.