National Institute of Neurological Disorders and Stroke 5R01NS114289-05

Role of oligomeric TDP-43 aggregate intermediates in ALS and frontotemporal dementia

This NIH grant supports research to understand the mechanisms of TDP-43 protein aggregation in neurological diseases such as ALS and frontotemporal dementia, aiming to identify toxic intermediates and develop intervention models.

Description

The goal of this grant is to elucidate key mechanisms of TDP-43 aggregation by uncovering how this process leads to pathology and neurotoxicity. TDP-43 aggregation is the hallmark of ALS and FTD, and also occurs in Alzheimer's disease. The project aims to identify and characterize toxic oligomeric intermediates of TDP-43, understand their role in disease progression, and develop models to prevent or reverse TDP-43 pathology.

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