National Institute of Arthritis and Musculoskeletal and Skin Diseases 5R01AR078903-04

Pathological Foundations of Skeletal Muscle After Volumetric Muscle Loss and Targets For Rehabilitation

NIH funded research project focused on understanding cellular and metabolic mechanisms in skeletal muscle after volumetric muscle loss to improve rehabilitation outcomes.

Description

This project aims to elucidate signaling mechanisms of diminished innervation, cellular mechanisms of oxidative adaptation, and the contribution of remaining muscle to whole-body metabolism to improve regenerative rehabilitation outcomes. It addresses large scale, traumatic orthopedic injuries such as volumetric muscle loss (VML) which cause lifelong limitations in daily function, long-term dysfunction, reduced mobility, co-morbidities, and often delayed amputation. Current rehabilitation strategies are insufficient, and understanding the cellular and metabolic mechanisms in remaining muscle tissue is critical.

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