Award
National Heart, Lung, and Blood Institute 5F31HL172636-02
Type 1-2 immune cross-regulation in the lung
Recipient
University of California, San Francisco
Award Amount
$46,473.00
Ceiling
$46,473.00
Awarded
August 29, 2025
Identifier
5F31HL172636-02
The award supports research on how type 1 and type 2 immune responses interact in the lung during viral infections, aiming to develop targeted therapies for pulmonary inflammation. The study will explore interferon-mediated regulation of lung immune cells to improve understanding of immune response and tissue repair in respiratory viral infections.
Description
This project investigates the cross-regulation of type 1 and type 2 immune responses in pulmonary viral infection to inform the design of new precision therapeutics to ameliorate pulmonary inflammation in humans. It focuses on the interactions between Type 1 lymphocytes and Type 2 lymphocytes in the lung resident immune system, particularly the role of interferon signaling in regulating these immune responses during viral infections such as Influenza A.