Award
National Institute of Diabetes and Digestive and Kidney Diseases 5R01DK106191-09
The CD226 costimulatory axis in type 1 diabetes
Recipient
University of Florida, Gainesville, FL
Award Amount
$590,577.00
Ceiling
$590,577.00
Awarded
January 26, 2026
Identifier
5R01DK106191-09
Research project funded by NIDDK to study the role of CD226 in immune regulation and type 1 diabetes, aiming to develop therapeutic interventions.
Description
The project aims to understand how variants in immune checkpoints contribute to loss of immune tolerance in type 1 diabetes (T1D), focusing on CD226, a gene associated with T1D risk. The study investigates the cellular and molecular mechanisms by which CD226 influences immune regulation, Treg stability, and disease progression, with potential for therapeutic interventions.