Award
NIH Reporter #5R01AG081237-04
Transcranial Magnetic Stimulation for MCI: A Phase II Dose-Response Study
Recipient
Not specified
Award Amount
$748,467.00
Ceiling
$748,467.00
Awarded
June 03, 2026
Identifier
5R01AG081237-04
A phase II clinical study to optimize dose levels of transcranial magnetic stimulation for improving depression and cognitive function in MCI patients.
Description
This project aims to establish dose-response curves for non-invasive brain stimulation (iTBS-rTMS) to improve depression and cognitive function in patients with Mild Cognitive Impairment (MCI). The study involves a double-blind, randomized sham-controlled phase II trial with various dose levels of active/sham stimulation. The goal is to optimize therapeutic delivery and understand functional connectivity changes post-treatment.