Award
National Institute of General Medical Sciences 2R35GM138085-06
Stress-modified growth signaling in dynamic nutrient environments
Recipient
Children's Hospital of Philadelphia, Philadelphia, PA, United States
Award Amount
$489,500.00
Ceiling
$489,500.00
Awarded
May 19, 2026
Identifier
2R35GM138085-06
The project investigates molecular mechanisms by which nutrient stress affects cell division and differentiation, focusing on stress-modified pro-growth signaling pathways in T-cells, to inform new therapeutic strategies.
Description
This NIH grant project aims to elucidate how stress modifies canonical pro-growth gene regulatory networks at the levels of transcription and translation in dynamic nutrient environments, with implications for developing innovative therapies for cancer, inflammation, and disease.