Award
National Institute of Neurological Disorders and Stroke 5R01NS126981-04
Prenatal inflammation disrupts blood-brain barrier development and long-term function
Recipient
Children's Hospital of Los Angeles
Award Amount
$408,852.00
Ceiling
$408,852.00
Awarded
December 12, 2025
Identifier
5R01NS126981-04
NIH awarded a research grant to study the impact of prenatal inflammation on blood-brain barrier development and long-term neurovascular function using mouse models, focusing on molecular mechanisms like COX2.
Description
This NIH research grant project aims to characterize how gestational inflammation disrupts fetal blood-brain barrier formation and function, leading to long-term neurovascular dysfunction and neuroinflammation in offspring. Using a mouse model, the study investigates molecular pathways such as COX2 involved in these effects, with implications for neurodevelopmental disorders.