Award
National Heart, Lung, and Blood Institute 5R01HL172872-02
Targeting Angiopoietin-like 4 (ANGPTL4) in Severe Community Acquired Pneumonia
Recipient
University of Washington, Seattle, WA, United States
Award Amount
$779,697.00
Ceiling
$779,697.00
Awarded
January 30, 2026
Identifier
5R01HL172872-02
This award funds research to investigate the role of ANGPTL4 in severe community-acquired pneumonia, aiming to understand its impact on patient outcomes and explore therapeutic interventions.
Description
The research aims to evaluate the role of angiopoietin-like 4 (ANGPTL4) as a mediator in adverse outcomes in community-acquired pneumonia (CAP) caused by viruses and bacteria. The project includes clinical and pre-clinical studies to understand the relationship between ANGPTL4 levels and patient outcomes, causal relationships via Mendelian randomization, and the role of ANGPTL4 in pneumonia models.