Award
National Institute of Allergy and Infectious Diseases (NIAID) 5R01AI187588-02
Deciphering Genetic Susceptibility of Pemphigus through Immunomics
Recipient
University of North Carolina Charlotte
Award Amount
$761,942.00
Ceiling
$761,942.00
Awarded
July 27, 2026
Identifier
5R01AI187588-02
This award funds research applying advanced multi-omics techniques to understand genetic susceptibility and disease mechanisms of pemphigus, an autoimmune blistering skin disease, aiming to identify causal variants and reactive antigens.
Description
Pemphigus is an autoimmune blistering skin disease that occurs sporadically across the globe but is triggered by still unknown environmental antigens in endemic areas. Although its etiology is poorly known, it has been demonstrated that the variation of the extended major histocompatibility complex (MHC) is strongly associated with a differential risk of developing pemphigus. Here, we will apply State-of-the-Art multi-omics approaches to discover causal variants, reactive antigens, and disease mechanisms.