Award
NIH Reporter #5R01HL180328-02
Targeting Regulatory T cells for Factor VIII Tolerance
Recipient
Stanford University
Award Amount
$758,254.00
Ceiling
$758,254.00
Awarded
August 19, 2026
Identifier
5R01HL180328-02
The project aims to understand and prevent the development of inhibitors against Factor VIII in hemophilia A patients by studying regulatory T cells and exploring erythropoietin as a preventive therapy.
Description
This research focuses on understanding the failure of immune regulation involving regulatory T cells (Tregs) in hemophilia A patients who develop inhibitors against Factor VIII (FVIII). It explores the potential of erythropoietin (EPO) to expand Tregs and prevent inhibitor formation, aiming to develop targeted therapies for inhibitor prevention. The project involves mouse models, human Treg analysis, and spleen organoid models to study immune responses and test therapeutic strategies.