Award
National Institute of Arthritis and Musculoskeletal and Skin Diseases 1R01AR085957-01A1
Role of Macrophages in Inflammation and Degeneration of the Intervertebral Disc
Recipient
Columbia University Health Sciences, New York, NY, United States
Award Amount
$636,479.00
Ceiling
$636,479.00
Awarded
April 21, 2026
Identifier
1R01AR085957-01A1
This NIH research grant funds a study on how macrophages contribute to inflammation and degeneration in intervertebral discs, aiming to develop therapeutic interventions for discogenic back pain.
Description
Research grant to study the role of monocyte-derived macrophages in painful disc degeneration and the contributions of CCL2/CCR2 signaling on macrophage migration into the intervertebral disc using in vivo mouse and rat models. The project aims to identify inflammatory mechanisms and evaluate a CCL2 neutralizing antibody as a potential therapy.